Host miRNAs regulate Escherichia coli O157 mucosal colonization through host-mucosa-attached microbiota interactions in calves.

ABSTRACT:

Introduction

Host responses to pathogen colonization are central to understanding host homeostasis dynamics. Here, we used Shiga toxin (Stx)-producing Escherichia coli (STEC) O157 as an example to illustrate how pathogen colonization alters host-microbiome interactions and stimulates host responses. The STEC O157 is a critical foodborne pathogen, and cattle are the major asymptotic carrier with rectal anal junction (RAJ) being the major colonization site, leading to the transmission of this organism through the production chain. Therefore, this study leverages the multi-omics to evaluate host mechanisms to STEC O157 and to illustrate how mucosa-attached microbiome together with host miRNAs respond to the colonization of STEC O157.

Results

The calf model was orally challenged

SUBMITTER: Pan Z 

PROVIDER: S-EPMC12548129 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature