USP9X-triggered ferroptosis mediates follicular atresia via deubiquitinating Beclin1 in chicken.

ABSTRACT:

Background

Follicular atresia, a complex degenerative process regulated by multiple molecular mechanisms, significantly affects female reproductive performance in animals. While granulosa cell (GC) apoptosis has been well established as a primary mechanism underlying follicular atresia, the potential involvement of ferroptosis, which is an iron-dependent form of regulated cell death, remains largely unexplored in chickens.

Results

Using a tamoxifen (TMX)-induced avian model of follicular atresia, we demonstrated that ferroptosis plays a critical role in follicular degeneration. Inhibition of ferroptosis through pharmacological agents significantly restored follicular function, underscoring its potential as a therapeutic target. Notably, we observed a significant upregulation

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12548185 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature