Genomic DNA methylation profile in peripheral blood of children with congenital biliary dilatation.

ABSTRACT:

Background

Congenital biliary dilatation (CBD) is a prevalent congenital biliary disease in children, particularly in Asian populations, yet its etiology remains poorly understood. This study aimed to investigate the genome-wide DNA methylation profile in the peripheral blood of children with CBD to identify potential epigenetic mechanisms involved in its pathogenesis.

Methods

Genome-wide DNA methylation profiles were compared between whole blood samples from 37 children with CBD and 24 healthy controls using the Illumina Infinium Human MethylationEPIC (850 K) BeadChip. Bioinformatic analyses were performed to identify differentially methylated positions (DMPs) and regions (DMRs), and functional enrichment analysis was conducted on associated genes.

Results

We identif

SUBMITTER: Wang C 

PROVIDER: S-EPMC12548212 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature