Exploring genotype-phenotype correlation of FSHR polymorphisms in polycystic ovary syndrome.

ABSTRACT:

Purpose

Single nucleotide polymorphisms (SNPs) in FSHR were reported to increase PCOS susceptibility. The present study was conducted to analyse the association of FSHR polymorphisms (rs1394205, rs11692782, and rs2349415) with PCOS in Punjab, India.

Methods

A case-control study comprised of 823 women (443 PCOS cases and 380 healthy controls). Along with anthropometric measurements, lipid and hormonal profiles (LH, FSH, and testosterone levels) were also recorded. The genotyping of FSHR polymorphisms was performed with PCR-RFLP method. Continuous variables were compared using the student's t-test while the genetic association analysis was performed utilizing chi-square, binary logistic regression, and odds ratio with a 95% confidence interval. All the statistical analyses wer

SUBMITTER: Kaur M 

PROVIDER: S-EPMC12548221 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature