Synthesis and characterization of core-shell mussel inspired magnetic molecularly imprinted polymer nanoparticles for the solid phase extraction of levofloxacin in human plasma.

ABSTRACT: Determination of pharmaceuticals in biological matrices is crucial for pharmaceutical development, toxicological studies, and therapeutic drug monitoring. Accurate quantification of drugs in plasma requires reliable analytical techniques; however, the complexity of biological fluids hinders direct analysis without an effective sample preparation step. In this study, Fe₃O₄ was synthesized using mussel-inspired magnetic molecularly imprinted polymer nanoparticles (MIP NPs) through a single-step auto-polymerization process with levofloxacin as the template and methyldopa as the monomer. The integration of Fe₃O₄ core synthesis, self-polymerization, and molecular imprinting in a single step provides a unique and streamlined methodology, reducing fabrication complexity and time. The prepared Fe₃

SUBMITTER: Mouhamed AA 

PROVIDER: S-EPMC12548232 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature