Proteomic and histopathologic profiling reveal molecular features and clinical biomarkers of coronary atherosclerosis.

ABSTRACT: The molecular features of coronary atherosclerosis progression remain incompletely understood. A comprehensive characterization of coronary proteome dynamics during atherosclerosis progression could facilitate the identification of novel biomarkers for early detection of plaque initiation and risk assessment of plaque destabilization. We performed proteomics on human coronary artery specimens representing five progressive histopathologic stages of atherosclerosis according to the modified AHA classification, including adaptive intimal thickening (AIT), pathological intimal thickening (PIT), fibroatheroma (FA), thin cap fibroatheroma (TCFA), and ruptured plaque (RP). The results revealed progressive dysregulation of complement and coagulation cascades and extracellular matrix (ECM) organiza

SUBMITTER: Xu X 

PROVIDER: S-EPMC12548267 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature