Baculovirus 25K hijacks host UAP56 to facilitate nuclear export of viral mRNA in insect cells.

ABSTRACT: Bombyx mori nucleopolyhedrovirus (BmNPV) is a baculovirus that hijacks host genes to cause viral infections. UAP56 is highly conserved in different species. Previous studies have shown that UAP56 is involved in several viral infections. However, its role in insect-baculovirus interactions remains unknown. In this study, we aimed to identify which BmNPV proteins interact with host UAP56 and to characterize the associated mechanism underlying viral infection using a BmNPV-silkworm model. Our data indicated that CCT018159, an inhibitor of UAP56, could suppress the proliferation of BmNPV and that the addition of CCT018159 within 12 h post-infection had a significant protective effect on BmE cells. To identify the interacting viral proteins, recombinant UAP56-GST was constructed through

SUBMITTER: Xiao S 

PROVIDER: S-EPMC12548385 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature