HCC-derived SNU cell lines as model systems to study HBV life cycle.

ABSTRACT: Human SNU cell lines, derived from hepatocellular carcinomas associated with chronic hepatitis B virus (HBV) infection, were examined. The analysis of intracellular RNA and DNA markers of HBV replication and examination of HBV RNA readss coverage of selected regions on HBV-related RNAs and polyadenylation positions within HBV sequence using RNA-sequencing suggested the absence of HBV replication in SNU-423, SNU-368, SNU-398, SNU-182, SNU-449, SNU-475, SNU-354, SNU-739, and SNU-387 cells, while SNU-761 and SNU-886 still could maintain residual HBV replication. The undetectable intracellular HBV core antigen (HBcAg) and absence of significant levels of secreted core-associated and virion-associated HBV DNA confirmed the absence or profound suppression of HBV replication in parental SNU cell

SUBMITTER: Zaiets I 

PROVIDER: S-EPMC12548393 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature