Adaptation to cinnamaldehyde shapes <i>Pseudomonas aeruginosa</i> resistance to major antibiotics.

ABSTRACT: In France, the use of essential oils to treat bacterial infections is common, with approximately 40% of cystic fibrosis patients regularly using these natural products to control infections caused by Pseudomonas aeruginosa often in combination with their antibiotic treatments. Previous research has demonstrated that prolonged exposure of P. aeruginosa PA14 to cinnamaldehyde (CNA), the main component of cinnamon essential oil, can select for mutants resistant to β-lactams through overproduction of the MexAB-OprM efflux pump, some of which are also hypersusceptible to aminoglycosides and colistin. We showed here that this hypersusceptibility is not due to an efflux defect, as the deletion of MexXY(OprM)-the specific efflux pump for aminoglycosides-still results in decreased min

SUBMITTER: Dubois E 

PROVIDER: S-EPMC12548396 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature