Multimodal characterization of the responsiveness of eight hepatitis D virus genotype isolates to interferon-alpha treatment.

ABSTRACT: Chronic hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis. Although humans produce 12 subtypes of interferon-alpha (IFN-α), IFN-α2a has been the only commonly used treatment against HDV. Previously, we characterized eight HDV genotype isolates with varying replication kinetics. Herein, we systematically investigated the antiviral efficacy of IFN-α2a and other IFN-α subtypes against HDV genotypes 1-8 during de novo infection, cell mitosis, and in quiescent cells. Our findings revealed that IFN-α2a exhibits potent but varied efficiency against HDV 1-8 isolates upon de novo infection and cell mitosis. Conversely, HDVs in resting cells are resistant to IFN-α2a treatment and the IFN-containing cytokine cocktail collected from peripheral blood mon

SUBMITTER: Ding Y 

PROVIDER: S-EPMC12548406 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature