Cytoplasmic translocation of tripartite motif-containing 28 is critical for PRRSV-induced autophagy through promoting Vps34-Beclin1 complex formation.

ABSTRACT: Autophagy, as a highly conserved cellular metabolic regulation mechanism, is a double-edged sword and plays multiple roles in viral infections processes. As a member of the Arteriviridae family within the order Nidovirales, the porcine reproductive and respiratory syndrome virus (PRRSV) induces cell autophagy both in vitro and in vivo. However, the direct or indirect causation of autophagy by PRRSV remains unclear. Identified as an autophagy-related factor, tripartite motif-containing 28 (TRIM28) shows an undefined relationship with autophagy during PRRSV infection. This study investigates the dynamic changes in autophagy and TRIM28 during PRRSV infection, revealing that PRRSV Nsp4 is identified as a key component responsible for the nuclear export of TRIM28 via a CRM1-depend

SUBMITTER: Chen M 

PROVIDER: S-EPMC12548422 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature