CSAD inhibits excessive inflammation during viral infections through the NF-κB signaling pathway.

ABSTRACT: Studies have shown that 129 mice generate more severe inflammatory responses than C57BL/6 (B6) mice shortly after influenza virus infection. However, the mechanisms for regulation of the magnitudes and kinetics of innate immune responses in different hosts remain to be fully understood. In this study, we found that cysteine sulfinic acid decarboxylase (CSAD), an essential enzyme in the taurine synthesis pathway, inhibits excessive inflammation after viral infection. CSAD KO mice in B6 background initiate stronger inflammatory responses and are more vulnerable to viral infections, exhibiting a phenotype resembling 129 mice. Interestingly, CSAD is differentially expressed in 129 and B6 mice; CSAD is highly expressed in B6 mice than in 129 mice. CSAD inhibits the NF-κB signaling pathway durin

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12548428 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature