Batch Synthesis of Primaquine Diphosphate Anti-Malarial Drug.

ABSTRACT: An improved three-step synthesis route toward Primaquine Diphosphate is reported herein. The anti-malarial drug was obtained via n-alkylation of readily available potassium phthalimide, followed by reductive amination and room temperature methylaminolysis-assisted phthalimido deprotection of the key intermediates to furnish Primaquine Diphosphate in 47% overall isolated yield.

SUBMITTER: Akwi FM 

PROVIDER: S-EPMC12548519 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature