Diabetes and Obesity Modify the Effect of Alcohol Consumption on Carbohydrate-Deficient Transferrin.

ABSTRACT:

Aims

Serum levels of carbohydrate-deficient transferrin (CDT, the sum of its asialylated and disialylated glycoforms) are a commercial marker of alcohol abuse. Our aim was to investigate the potential influence of metabolic factors on serum CDT levels and the predictive value of transferrin glycoforms for the development of type 2 diabetes in a general adult population.

Materials and methods

We measured serum CDT levels by capillary electrophoresis in 1516 individuals (median age 52 years; 55.3% women) randomly selected from the general adult population of a municipality.

Results

Insulin resistance and the associated body mass index and diabetes modified the effect of alcohol consumption on CDT levels; i.e., CDT in heavy drinkers was lower in individuals with obesity

SUBMITTER: Gonzalez-Vidal T 

PROVIDER: S-EPMC12548559 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature