Engineering polyamidoamine dendrimer nanoparticles for targeted drug delivery to proximal tubular cells after renal ischemia/reperfusion injury.

ABSTRACT: Acute kidney injury (AKI) is a prevalent and potentially severe clinical condition that currently lacks effective therapeutic options. Major obstacles to treatment include the glomerular filtration barrier, which restricts access of many therapeutic agents to injured tubular epithelial cells, and off-target effects of potent drugs on uninvolved organs. Given the susceptibility of proximal tubule (PT) cells to multiple forms of injury, we identified the folate receptor (FOLR1), highly expressed in both LTL-positive healthy and KIM-1-positive injured PT cells, as a potential target for cell-specific drug delivery. We synthesized and characterized folic acid (FA)-conjugated, acetylated polyamidoamine dendrimer [FA-G4(-Ac₁₀)] nanoparticles, which are capable of crossing the glomerul

SUBMITTER: Li X 

PROVIDER: S-EPMC12548566 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature