Association of plasma ceramides with short-term and lifetime risk of MACE in coronary atherosclerotic heart disease patients: a prospective cohort study.

ABSTRACT:

Objectives

To develop a CERT SCORE utilising both odd-chain and even-chain ceramide species, and to evaluate its association with short-term and lifetime cardiovascular risk in patients with coronary atherosclerotic heart disease (CAD).

Design

Prospective cohort study.

Setting

A patients-based cohort in the Beijing Anzhen Hospital, Capital Medical University.

Participants

CAD patients were defined as having at least one coronary artery stenosis of ≥50% as assessed by coronary angiography or CT angiography.

Main outcomes and measures

Major adverse cardiac events (MACE) including all-cause death, myocardial infarction, heart failure, cerebral infarction and readmission.

Results

We quantified 13 ceramide species and calculated the ratios of Cer(d18:1

SUBMITTER: Li X 

PROVIDER: S-EPMC12548602 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature