Ketogenic diet strategy in patients with sepsis: a multicentre prospective randomised interventional trial protocol.

ABSTRACT:

Introduction

Sepsis is defined as a dysregulated host response to infection, associated with high morbidity and mortality rates globally. Recent studies have indicated that increasing ketone levels may be beneficial for patients with sepsis. Existing research has established the feasibility, effectiveness and safety of the ketogenic diet in sepsis patients. This study aims to further clarify the organ-protective effects of a ketogenic diet in sepsis patients through a multicentre randomised controlled trial.

Methods

This is a multicentre, prospective, randomised controlled trial conducted in five intensive care units (ICUs) in China. The intervention group will receive a ketogenic diet, while the control group will receive standard enteral nutrition. The primary outcome is t

SUBMITTER: Wang J 

PROVIDER: S-EPMC12548615 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature