Jugular Venous Catheterization-Enhanced CT Angiography for In Vivo 3D Visualization of Cardiopulmonary Vasculature in Sprague-Dawley Rats.

ABSTRACT: Current in vivo imaging techniques for cardiopulmonary vascular evaluation in Sprague-Dawley (SD) rats face limitations, including structural disruption, inadequate contrast filling, and invasiveness. This study developed a reliable, minimally invasive computed tomography angiography (CTA) technique via jugular vein catheterization for enhanced cardiopulmonary vascular imaging in live SD rats. Jugular vein catheterization was performed in 22 anesthetized healthy male SD rats (320-480 g), followed by dual-source CT angiography with iopamidol contrast. Three-dimensional vascular reconstruction was performed, and pulmonary artery width alongside left and right ventricular diameters was measured. CT-derived measurements were compared with ultrasound data using Bland-Altman analysis. CTA achiev

SUBMITTER: Gao T 

PROVIDER: S-EPMC12548699 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature