Retrospective detection of severe fever with thrombocytopenia syndrome virus (SFTSV) revises timeline of emergence in Thailand.

ABSTRACT: To comprehend the time of emergence and extent of cryptic circulation for Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) in Thailand, plasma specimens collected from patients at Siriraj Hospital, Bangkok, Thailand presenting with acute undifferentiated febrile illness (AUFI) were characterized by next-generation sequencing (NGS). Molecular and serological diagnostics were developed to screen for viral RNA and antibodies. Phylogenetic and phylogeographic analyses were performed using sequences generated from this study, publicly available genomes, and unsampled taxa to enhance temporal and geographic resolution. NGS detected SFTSV in 7 individuals with a median age of 73 years. Clinical manifestations ranged from low-grade fever and altered consciousness to multi-organ failure an

SUBMITTER: Perez LJ 

PROVIDER: S-EPMC12548732 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature