Osteitis fibrosa cystica recovery following parathyroidectomy for primary hyperparathyroidism: a case series and review of literature.

ABSTRACT: Osteitis fibrosa cystica (OFC) is an extreme manifestation of accelerated bone resorption in primary hyperparathyroidism (PHPT), rarely encountered nowadays. Bone mineral density gain following parathyroidectomy (PTx) is well documented, while little is known regarding the timeline of lytic lesions remineralization and recovery. We present three patients with OFC, surgically treated for PHPT, with clinical, biochemical, and advanced radiological (CT or MRI) post-PTx follow-up. Additionally, we review published OFC case reports that include serial imaging of bony lesions following PTx. All patients received calcium, magnesium and alphacalcidiol supplementation post-PTx with serum calcium, PTH, and alkaline phosphatase gradually normalizing. Patients 1 and 2 exhibited an impressive remineral

SUBMITTER: Eden-Friedman Y 

PROVIDER: S-EPMC12548736 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature