Measuring the continuation of antidepressant exposure prior to, during, and after pregnancy: A scoping review protocol.

ABSTRACT:

Objective

The goal of this scoping review is to summarize how prior studies have measured antidepressant continuation/discontinuation prior to, during, and after pregnancy.

Introduction

Pregnant individuals and healthcare providers are faced with difficult decisions about whether to continue antidepressants in pregnancy due to the historical exclusion of pregnant women from clinical trials and the lack of rigorous evidence to support these decisions. Prior studies examining the effects of pre- and perinatal antidepressant use on perinatal outcomes using observational data have been inconsistent, primarily due to the binary (ever/never) categorization of exposure, which may not accurately reflect real-world use.

Inclusion criteria

The population for this review consist

SUBMITTER: Tailor LS 

PROVIDER: S-EPMC12548859 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature