Genetic diversity of Trypanosoma cruzi in individuals with chronic Chagas disease in the Northern Minas Gerais and Vale do Jequitinhonha regions, Minas Gerais, Brazil.

ABSTRACT: Chagas disease, caused by the hemoflagellate parasite Trypanosoma cruzi, is a major public health problem in Latin America due to its high prevalence and significant morbidity and mortality. The T. cruzi is classified into seven distinct genetic groups (TcI-TcVI) and TcBat, know as Discrete Typing Units (DTUs). Understanding DTU diversity is essential for improving diagnostic and therapeutic strategies and strengthening epidemiological surveillance. This study aimed to investigate the genetic diversity of T. cruzi in individuals with chronic Chagas disease from endemic municipalities in Northern Minas Gerais and the Jequitinhonha Valley, Brazil. It also evaluated associations between DTUs and age, parasitic load, antibody levels, and cardiac disease severity in participants from the SaMi-T

SUBMITTER: Xavier EMS 

PROVIDER: S-EPMC12548877 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature