Multiscale networks in Alzheimer's disease identify brain hypometabolism as central across biological scales.

ABSTRACT: Alzheimer's disease encompasses multiple biological scales, spanning molecular factors, cells, tissues, and behavioral manifestations. The interplay among these scales in shaping the clinical phenotype is not yet fully comprehended. In particular, there is great interest in understanding the heterogeneity of the clinical aspects of AD in order to improve treatment and prevention, by targeting those aspects most susceptible to the disease. Here we employed a systems biology approach to address this issue, utilizing multilayer network analysis and deep phenotyping. This integrative analysis incorporated genomics, cerebrospinal fluid biomarkers, tau and amyloid beta (Aβ) PET imaging, brain MRI data, risk factors, and clinical information (cognitive tests scores, Clinical Dementia Rating and c

SUBMITTER: Lara-Simon E 

PROVIDER: S-EPMC12548887 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature