TRNA modifications as regulators of bacterial virulence and stress responses.

ABSTRACT: Bacteria are recognized for their ability to adapt their lifestyle to the environment. Specifically, when considering pathogenic bacteria, their capacity to respond to stress and switch to a virulent state through gene regulation is crucial. One of the mechanisms that enables regulation of gene expression at the translational level is RNA modification. These chemical changes produced by specific enzymes are present on all types of RNAs and can modulate translational efficiency by influencing the structure of RNA molecules, the codon usage bias, the interaction with other molecules, or the efficiency of ribosome action. Transfer RNA (tRNA) is the most modified RNA in the cell, with modifications in the core body of the tRNA primarily affecting the stability and flexibility of the structure

SUBMITTER: Teixeira C 

PROVIDER: S-EPMC12548931 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature