Sustainable Natural Product Glycosylation: A Critical Evaluation of Biocatalytic and Chemical Approaches.

ABSTRACT: The glycosylation of natural products can significantly enhance their physicochemical properties, with numerous synthetic and biocatalytic methodologies continuously being developed, each presenting unique advantages and challenges. Biocatalytic methods are often presumed to be more sustainable alternatives to chemical approaches; however, their environmental and economic viabilities require critical evaluation. This review summarizes the recent advancements in natural product glycosylation and provides a comprehensive techno-economic and environmental assessment based on yield, titer, rate, environmental factor, and impact on endpoint categories using a life cycle impact assessment approach. Although biocatalytic methods are highlighted for their superior yields, they are frequently hinde

SUBMITTER: Mejia-Otalvaro F 

PROVIDER: S-EPMC12548952 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature