Molecular dynamics of the matrisome across sea anemone life history.

ABSTRACT: The evolutionary expansion of extracellular matrix (ECM) molecules has been crucial for the establishment of cell adhesion and the transition from unicellular to multicellular life. Members of the early diverging metazoan phylum Cnidaria offer an exceptionally rich perspective into the metazoan core adhesome and its original function in developmental and morphogenetic processes. Here, we present the ensemble of ECM proteins and associated factors for the starlet sea anemone Nematostella vectensis based on in silico prediction and quantitative proteomic analysis of decellularized mesoglea from different life stages. The integration of the matrisome with single-cell transcriptome atlases shows that gastrodermal cells are the primary producers of Nematostella's complex ECM, conf

SUBMITTER: Bergheim BG 

PROVIDER: S-EPMC12549020 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature