YWHAH‑driven autophagy via MAPK/ERK signaling enhances CRC cell migration and invasion.

ABSTRACT: The present study investigated the role of YWHAH in colorectal cancer (CRC) progression, focusing on its regulation of autophagy via the MAPK/ERK signaling pathway and subsequent effects on cell migration and invasion. Clinical sample analysis revealed that YWHAH was highly expressed in CRC tissues, associating with poor differentiation, advanced TNM stage, lymph node metastasis, vascular invasion and unfavorable prognosis. In vitro experiments showed that YWHAH overexpression promoted proliferation, and epithelial‑mesenchymal transition of CRC cells, while inhibiting apoptosis. Conversely, YWHAH knockdown exerted opposite effects. Autophagy assays demonstrated that YWHAH knockdown enhanced autophagy by upregulating autophagy related 7 and LC3II/I and downregulating P62, whereas ove

SUBMITTER: Li Q 

PROVIDER: S-EPMC12549071 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature