Dysregulated programmed cell death of intestinal epithelial cells in ulcerative colitis: Molecular mechanisms and novel therapeutic interventions (Review).

ABSTRACT: Ulcerative colitis (UC), a chronic idiopathic inflammatory bowel disease affecting the colonic mucosa, has seen a rising global incidence and poses a growing public health challenge. The clinical presentation typically includes recurrent abdominal pain, hematochezia, weight loss and structural damage to the colonic epithelium, substantially impacting patients' quality of life. Recent research has underscored the role of intestinal barrier dysfunction as a fundamental driver of persistent inflammation and disease progression in UC. Intestinal epithelial cells (IECs) form a monolayer through tight intercellular junctions and constitute the primary defense against luminal pathogens. Dysregulation of programmed cell death pathways in IECs such as apoptosis, necroptosis, pyroptosis, ferroptosis

SUBMITTER: Wu B 

PROVIDER: S-EPMC12549076 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature