Calcium chloride within carbon dioxide absorbents prevents Compound A production from sevoflurane.

ABSTRACT: Calcium chloride (CaCl₂)-containing carbon dioxide (CO₂) absorbers are characterized by their ability to produce almost no pentafluoroisopropenyl fluoromethyl ether (Compound A), a potentially nephrotoxic byproduct of sevoflurane, in vitro. However, the precise role of CaCl₂ in this process remains unclear. We aimed to clarify the role of CaCl₂ in vitro and determine whether CaCl₂-containing CO₂ absorbents produce Compound A during prolonged surgery under low- and minimal-flow sevoflurane anesthesia using Japanese brand Yabashi Lime-f (YL-f). In vitro, a reaction between 1 L of sevoflurane gas (8%) with 5% CO₂ and an absorbent specimen (20 g) with or without water was performed in an artificial closed-circuit syst

SUBMITTER: Ando T 

PROVIDER: S-EPMC12549110 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature