Burden of psychiatric disease inversely correlates with Alzheimer's age at onset.

ABSTRACT:

Introduction

Depression is regarded as a risk factor for Alzheimer's disease (AD). Associations between AD and other psychiatric disorders are less clear.

Methods

We screened 1,500 AD UCSF Memory and Aging Center patients for prevalence of psychiatric disorders and compared results to 8,267 NACC AD participants.

Results

AD with depression, anxiety, or post-traumatic stress disorder were significantly younger at age at onset than AD without (p < 0.001; p < 0.001; p < 0.05). Comorbidity of depression, anxiety and PTSD led to further decreases in AD age at onset. Within the NACC cohort, we further demonstrated an inverse relationship between the severity of depression and anxiety symptoms and AD age at onset.

Discussion

Depression, anxiety, and post-traumatic stre

SUBMITTER: Eijansantos E 

PROVIDER: S-EPMC12549220 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature