Adherence to a healthy lifestyle in association with female infertility risk: the mediating role of uric acid.

ABSTRACT:

Background

Infertility poses a significant health challenge for reproductive-aged women globally and could be shaped by both genetic risks and lifestyle factors. Existing studies predominantly focus on individual lifestyle components, while their joint effect on infertility remains limited.

Methods

This large cross-sectional study analyzed data from 2,067 women aged 18-44 years, sourced from the National Health and Nutrition Examination Survey spanning 2013 to 2020. Six modifiable healthy lifestyle factors were included: current non-tobacco smoking, non-excessive alcohol drinking (1-14 g/day), sufficient physical activity (≥150 min/week), healthy diet (top 40% of Healthy Eating Index-2015 score), optimal waist circumference (<80 cm), and adequate sleep duration (7-9 h/day).

SUBMITTER: Huang Z 

PROVIDER: S-EPMC12549233 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature