Curcumin triggers reactive oxygen species-mediated apoptosis and suppresses tumor growth in metastatic oral squamous cell carcinoma.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) remains a major clinical challenge with limited effective treatment options. In this context, several natural compounds (NC), such as curcumin, have shown promising effects in OSCC. However, there is still limited evidence about curcumin's effects on cell death in metastatic OSCC cells and its cytotoxicity in preclinical models. To address this gap, this study aimed to evaluate the effects of curcumin on mitochondrial stress-induced apoptotic cell death and its cytotoxicity in preclinical models.

Methods

Curcumin's cytotoxicity was assessed in both 2D (monolayer) and 3D (spheroid model) cell cultures using a luminescent assay. Additionally, morphological parameters (FSC and SSC), apoptosis, and reactive oxygen species (ROS) prod

SUBMITTER: Ramos TCF 

PROVIDER: S-EPMC12549243 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature