Mechanistic insights into modified Danggui Buxue Decoction for diabetic retinopathy via integrative analysis.

ABSTRACT:

Objective

This study explores the therapeutic potential and mechanisms of Modified Danggui Buxue Decoction (MDBD) in diabetic retinopathy (DR) using network pharmacology, bioinformatics, machine learning, Mendelian randomization (MR), molecular docking, and in vitro experiments.

Methods

A network pharmacology was constructed in order to screen core components and targets. Analysis of samples from the GEO database was performed for target and immune cell analysis, resulting in the identification of significantly differentially expressed core genes (SDECGs). A machine learning model was utilized to screen feature genes and construct nomogram. Preliminary validation was carried out using molecular docking, another GEO dataset, and MR. Subsequently, samples were clustered

SUBMITTER: Poon LY 

PROVIDER: S-EPMC12549254 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature