The fat-mass and obesity-associated gene rs9939609 T allele is prominent among the native Mexican population and is associated with risk for Type 2 diabetes and metabolic dysfunction-associated steatotic liver disease.

ABSTRACT:

Background

The fat mass and obesity-associated (FTO) rs9939609 T>A polymorphism is associated with excess body fat and metabolic disturbances, including Type 2 diabetes (T2D) and metabolic dysfunction-associated steatotic liver disease (MASLD). However, the genetic effect of the T and the A alleles on the development of these diseases may vary among populations.

Objective

This study aimed to determine the distribution of the FTO rs9939609 T>A polymorphism in West Mexican populations with variable genetic ancestry and analyze its effect on an admixed cohort's anthropometric and metabolic profile.

Methods

In a cross-sectional study, 684 unrelated adults from West Mexico were included. Subjects were grouped as Amerindian (Wixárika and Nahuas) or admixed: Me

SUBMITTER: Sepulveda-Villegas M 

PROVIDER: S-EPMC12549268 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature