Multi-phases of islet beta-cell function change in type 2 diabetes mellitus and its influencing factors.

ABSTRACT:

Aims

Based on cross-sectional and follow-up data, we aimed to explore the continuous long-term pattern of beta-cell function change in type 2 diabetes and to analyze the relevant influencing factors.

Materials and methods

Data from 2898 type 2 diabetic subjects were retrospectively analyzed. Islet beta-cell function was evaluated by the homeostasis model assessed index (HOMA-β). The pattern of association between HOMA-β and disease duration coverup of 50 years were explored using non-linear regression approaches. Findings were replicated in longitudinal follow-up data from multi-centers. Influencing factors of both residual HOMA-β level and HOMA-β decline rate were investigated.

Results

We identified a model including three clear phases of HOMA-β change: an initial as

SUBMITTER: Cheng J 

PROVIDER: S-EPMC12549277 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature