Prevalence, severity, frequency and healthcare resource use of epilepsy among individuals with Rett Syndrome: analysis of data from a Rett Center of Excellence.

ABSTRACT:

Background

Individuals with Rett Syndrome (RTT) frequently experience comorbid epilepsy. Few studies have examined the impact of epilepsy healthcare utilization using real-world datasets among RTT. The objective of this study was to examine all-cause and epilepsy-related healthcare utilization among individuals with RTT using electronic health record (EHR) data and chart notes.

Methods

A retrospective comparative cohort analysis was performed among RTT individuals with and without epilepsy using EHR structured and abstracted clinical notes data. Epilepsy cases were stratified into severe (associated with prolonged or intractable seizures) and non-severe. RTT individuals with no epilepsy, non-severe epilepsy, and severe epilepsy were compared on seizure frequency and healthca

SUBMITTER: Rashid N 

PROVIDER: S-EPMC12549289 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature