Association between triglyceride-glucose and triglyceride glucose body mass index with risk of prediabetes: a multicenter Chinese medical examination cohort study.

ABSTRACT:

Background and aims

Although triglyceride-glucose (TyG) indices reliably identify insulin resistance and diabetes, their link to prediabetes risk is understudied. We analyze the associations of TyG and TyG-body mass index (TyG-BMI) with prediabetes risk in a Chinese population.

Methods

This retrospective cohort study used data from 11 urban physical-examination centers of the Rich Healthcare Group. A total of 161606 Chinese adults free of diabetes at baseline were included. Participants were categorized by quartiles of the TyG index and the TyG-BMI. Cox proportional hazards regression and Kaplan-Meier analyses were used to estimate the associations between these exposures and incident prediabetes. Restricted cubic splines with piecewise Cox models were applied to explore pot

SUBMITTER: Feng C 

PROVIDER: S-EPMC12549309 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature