TTK Defines a High-Risk Oral Squamous Cell Carcinoma Subtype Through Dual mTORC1/NF-κB Activation.

ABSTRACT:

Objective

Oral squamous cell carcinoma remains difficult to treat because of its marked tumor heterogeneity, highlighting the need to identify molecular subtypes with distinct therapeutic vulnerabilities. This study aimed to comprehensively characterize OSCC molecular subtypes and identify potential therapeutic targets.

Materials and methods

We conducted an integrated analysis combining single-cell and bulk RNA sequencing from 709 OSCC cases. Protein interactions were examined using mass spectrometry and immunoprecipitation assays. The functional roles of key regulators were evaluated through in vitro cell proliferation and invasion assays, RNA sequencing of knockdown cell lines, and in vivo xenograft models. Statistical analyses included differential gene expression analysi

SUBMITTER: Jin H 

PROVIDER: S-EPMC12549379 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature