Investigation of differences in mechanisms of die filling between a compaction simulator and a rotary press.

ABSTRACT: Die Filling is the critical process step in tableting as it determines the tablet weight and its variability as well as impacting tablet strength and defect propensity. Several studies have focused on modeling die filling on rotary presses, however none have investigated the matter on a compaction simulator. Therefore, the aim of this study is to characterize the die filling behavior on a compaction simulator and compare it to a laboratory scale rotary press. Special attention is paid to the complex interplay of process parameters, machine geometry and material properties. Experimental results are supported by a newly introduced physics-based calculation of the course of the exerted differential pressure as a main driver of die filling. On the compaction simulator, suction filling is shown

SUBMITTER: Kohlhaas B 

PROVIDER: S-EPMC12549384 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature