Transcriptomic and metabolomic insights from functionalized V-shaped <i>Lactiplantibacillus plantarum</i> towards mitigating <i>Candida albicans</i> virulence.

ABSTRACT: The genomic capacity of probiotic Lactobacilli enables producing bioactive metabolites that represent promising alternatives to antibiotics for combating food-borne and multi drug-resistant pathogens. The current study characterizes a global antagonistic potential of the probiotic bacterium Lactiplantibacillus plantarum, which demonstrates unique multicellular structuring triggered in response to acidic environments. We demonstrate the inhibitory potential of postbiotics derived from the V-shaped structured L. plantarum (VSLP) against Candida albicans. Using the liquid chromatography-mass spectrometry (LC-MS) profiling, we further identify different antibiofilm metabolites secreted during the VSLP formation. Transcriptomic studies reveal a notable upregulation of genes

SUBMITTER: Rajasekharan SK 

PROVIDER: S-EPMC12549387 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature