Identification of two distinct uveal melanoma subtypes based on the immune cell infiltration of the primary tumour.

ABSTRACT:

Background

Uveal melanoma (UM) is the most common intraocular malignancy, with poor prognosis in metastatic cases and limited response to conventional therapies. Despite advances in genetic stratification, the immunological landscape of primary UM remains poorly understood.

Methods

Secondary data generation of single-cell RNA sequencing (scRNA-seq) of primary class 1 and class 2 (loss of BAP1) UM tumours and flow cytometric analysis of 8 primary UM tumour biopsies were used to characterize the tumour microenvironment, cellular composition, tumour-immune cell interactions, and stromal marker expression associated with tumour progression and immune infiltration.

Results

scRNA-seq analysis revealed 16 distinct cell clusters, including melanocytes, T cells, macrophages, a

SUBMITTER: Panagiotidis K 

PROVIDER: S-EPMC12549448 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature