Assessment of tertiary lymphoid structures via ¹⁸F-FDG PET/CT scan in patients with pancreatic adenocarcinoma.

ABSTRACT: Pancreatic adenocarcinoma (PAAD) is one of the most malignancies with a poor prognosis. The immune phenotype of pancreatic cancer is remarkably complex, presenting a significant challenge to the efficacy of immunotherapy. Tertiary lymphoid structures (TLSs) are active zones composed of various immune cells, which reflect immune responses against cancer. TLSs have emerged as critical biomarkers for predicting immunotherapy outcomes, potentially reflecting alterations in the metabolic characteristics of the host. Accumulating evidence indicates that ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) may shed light on cancer immunology. The tumor environment is known to be associated with the metabolic activity and antitumor immunity

SUBMITTER: Yan Y 

PROVIDER: S-EPMC12549455 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature