Hypothyroidism is associated with radiation-induced pulmonary fibrosis.

ABSTRACT:

Introduction

Radiation-induced pulmonary fibrosis (RIPF) is a common late complication for breast cancer patients after radiation therapy (RT). Breast cancer patients are often accompanied by hypothyroidism. We therefore sought to evaluate the association between hypothyroidism and RIPF susceptibility.

Materials and methods

We retrospectively analyzed 781 breast cancer patients who underwent postoperative intensity-modulated radiation therapy (IMRT) between 2020 and 2021. Univariate and multivariate Cox regression analyses were used to evaluate the prevalence of hypothyroidism between patients with or without RIPF. Propensity score matching (PSM) was employed to balance baseline characteristics between the two groups. Analysis of the occurrence time of RIPF was performed usi

SUBMITTER: You J 

PROVIDER: S-EPMC12549523 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature