A thermo-sensitive peptide hydrogel loaded with paclitaxel and antimony nanosheets for synergistic photothermal-chemotherapeutic treatment of breast cancer.

ABSTRACT:

Introduction

Breast cancer is one of the most common cancers in the world. Paclitaxel (PTX), a potent chemotherapeutic agent, is widely used in cancer treatment but suffers from poor aqueous solubility and systemic toxicity.

Methods

In this study, we developed a thermo-sensitive peptide, TSP-5, which forms a stable hydrogel at 37 °C and dissociates upon heating to 45 °C to facilitate drug release. The hydrogel was co-loaded with PTX and photothermal agent antimony nanosheets (AM) for targeted delivery to tumor sites. Under near-infrared (NIR) laser irradiation, AM rapidly elevated the local temperature due to its high photothermal conversion efficiency, triggering hydrogel dissolution and subsequent PTX release. Simultaneously, AM-mediated photothermal therapy (PTT) contribu

SUBMITTER: Yan B 

PROVIDER: S-EPMC12549564 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature