Voluntary wheel running promotes lymphangiogenesis in slow-twitch muscle in young mice.

ABSTRACT:

Introduction

Lymphatic vessels contribute to tissue homeostasis. Although the lymphatic vessels in skeletal muscle are known to undergo structural changes under certain conditions, such as atrophy and injury, effects of exercise on intramuscular lymphatic vessels remain unclear.

Methods

This study was aimed at investigating whether 8 weeks of voluntary wheel running (VWR) induces histological changes in lymphatic and blood capillaries, and whether these responses are related to age and myofiber type. Young (3-month-old) and aged (18-month-old) male C57BL/6 mice were assigned to sedentary or VWR groups. The soleus (SOL; slow-twitch) and plantaris (PLAN; fast-twitch) muscles were analyzed using immunohistochemistry and quantitative polymerase chain reaction.

Results

In

SUBMITTER: Tamura Y 

PROVIDER: S-EPMC12549571 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature