Association between pan-immune-inflammation value and bone turnover markers in Chinese patients with osteoporotic fractures: a retrospective cross-sectional study.

ABSTRACT:

Background

Systemic inflammation has been linked to impaired bone remodeling and may contribute to the risk of osteoporotic fractures (OPFs). This study examined the relationship between baseline pan-immune-inflammation value (PIV) and bone turnover markers (BTMs) in patients hospitalized for the surgical treatment of OPFs.

Methods

In this retrospective cross-sectional study, 839 patients aged ≥50 years who were treated for osteoporotic fragility fractures between 2017 and 2024 were analyzed. PIV was calculated as (neutrophils × platelets × monocytes)/lymphocytes. BTMs included serum β-C-terminal telopeptide of type I collagen (β-CTX) and procollagen type I N-terminal propeptide (P1NP). Associations between log₂-transformed PIV and BTMs were assessed using multivariab

SUBMITTER: Wang JH 

PROVIDER: S-EPMC12549592 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature