Maternal circulating GPIHBP1 levels and neonatal outcomes in patients with gestational diabetes mellitus: a pilot study.

ABSTRACT:

Introduction

The prevalence of gestational diabetes mellitus (GDM) is significantly increasing. Hyperglycaemia and dyslipidaemia have been demonstrated to contribute to endothelial dysfunction linked to foetal-placental circulation. Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) is crucial for the lipolytic processing of TG-rich lipoproteins through the anchoring of lipoprotein lipase (LPL). In this study, circulating GPIHBP1 levels during pregnancy were evaluated, and their associations with hypertriglyceridaemia and the perinatal outcomes of GDM were evaluated.

Methods

This study included 12 pregnant women with GDM and 21 pregnant women with normal glucose tolerance (NGT).

Results

No significant differences in obstetrical

SUBMITTER: Watanabe M 

PROVIDER: S-EPMC12549623 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature