Allergic manifestations in inborn errors of immunity: a systematic scoping review.

ABSTRACT:

Background

Allergic diseases resulting from aberrant immune function are frequently observed in patients with inborn errors of immunity (IEI). However, the underlying monogenic disorders may not be initially diagnosed, which leads to delays in appropriate diagnosis and treatment. Although recent studies have highlighted the link between IEI and allergic conditions, earlier case series might not have been fully exploited.

Objective

To compile a comprehensive database of IEI cases in the literature, analyze the prevalence and characteristics of allergic diseases, and assess the latter's association with other forms of immune dysregulation.

Method

A systematic scoping review of the literature.

Results

A total of 738 articles (reporting on 3050 individual patients)

SUBMITTER: Marbet L 

PROVIDER: S-EPMC12549635 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature