Case Report: Therapeutic biopsy guided targeted therapy improves visual acuity and prolongs survival in bilateral uveal metastases as the initial presentation of lung adenocarcinoma.

ABSTRACT:

Background

Although uveal metastasis is common in lung cancer, reports of bilateral uveal metastasis as the initial symptom in lung adenocarcinoma patients undergoing intraocular biopsy are rare. Such cases typically portend poor outcomes, with a median survival of only 6.5 months. The current diagnostic gold standard involves intraocular biopsy (vitreous or choroidal), which carries significant risks, including tumor dissemination and retinal detachment. Crucially, these procedures are purely diagnostic, requiring additional interventions for local tumor control. This gap underscores the need for innovative strategies that integrate diagnosis, local therapy, and molecular profiling without compromising ocular function or survival outcomes.

Case presentation

A 40-year-old ma

SUBMITTER: Ou T 

PROVIDER: S-EPMC12549678 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature