Analysis of risk factors for major adverse cardiac events in patients with multiple myeloma.

ABSTRACT:

Objective

To identify risk factors for major adverse cardiovascular events (MACE) in patients with multiple myeloma (MM) and to evaluate the performance of an external risk-score-based stratification.

Methods

We retrospectively analyzed 162 newly diagnosed MM patients treated at Qingdao University Affiliated Hospital (2017-2023). Baseline demographics, comorbidities, laboratory and echocardiographic indices, and treatment exposures were collected. MACE (heart failure, acute coronary syndrome, malignant arrhythmias, cardiogenic shock, or cardiac sudden death) were adjudicated during therapy. Multivariable logistic regression identified independent risk factors. Progression-free survival (PFS) was compared by Kaplan-Meier analysis. An externally derived 0-4 point cardiovascula

SUBMITTER: Feng Y 

PROVIDER: S-EPMC12549688 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature